The season starts in the USA, Sweden and Norway, while a North London and Merseyside derby are set in England.
Find out how to catch our Matildas Abroad in action in our preview.
England
Kicking off with the Merseyside derby, Clare Wheeler's Everton will host rivals Liverpool. The last meeting between the two sides back in September saw the Toffees win 3-0 over the Reds.
Six points divide the the two teams on the table, with Wheeler's side occupying sixth place at the moment, with the midfielder playing a full shift in Everton's 0-0 draw with Leicester last weekend. This game will kick off on Saturday morning at 6:30 am AEDT.
Another derby will see Kyah Simon's Tottenham Hotspur host Caitlin Foord and Steph Catley's Arsenal in the North London derby, their last meeting ending in a 4-0 win over the Spurs.
The Gunners will be looking to pick up all three points and remain in contention for a top-four finish, with the side facing defeat in midweek UWCL quarter-final action.
This game will kick off on Sunday morning at 2:00 am AEDT.
Meanwhile, second-place Manchester United will host Mackenzie Arnold's West Ham United, with the Hammers looking to get back in the winners' circle after a 2-1 loss to Aston Villa in their last WSL outing.
Manchester United's last WSL fixture saw them go down 1-0 to Chelsea in their top-of-the-table clash. This game will kick off on Sunday morning at 4:30 am AEDT.
Next up, Mary Fowler, Hayley Raso and Alanna Kennedy's Manchester City will host Sam Kerr's ladder leaders Chelsea. The Blues come into the game off the back of a 1-0 win over Lyon in their UWCL quarter-final first leg.
Meanwhile, Manchester City were last in action during the Women's FA Cup, where they were knocked out in the quarter-finals by Aston Villa.
This game will kick off on Sunday morning at 10:40 pm AEDT.
Emily Gielnik's Aston Villa will host Courtney Nevin and Remy Siemsen's Leicester City, with the Foxes looking to climb off the bottom of the table.
Leicester's last meeting with the Villans ended in a 2-0 defeat, with Gielnik scoring in the fixture. This game will kick off on Monday morning at 12:00 am AEDT.
Lastly, Lydia Williams' Brighton & Hove Albion will be aiming to climb out of the relegation zone when they take on Reading FC. At the moment, only two points divide the two teams, with their last meeting ending in a 2-1 win for the Seagulls.
Brighton has faced three consecutive losses in the WSL. This game will kick off on Monday morning at 12:00 am AEDT.
USA
The eleventh season of the NWSL starts in the USA, with Emily Van Egmond's San Diego Wave FC hosting the Chicago Red Stars in last season's quarter-final rematch.
Wave's inaugural season saw them advance to the semi-finals, knocking the Red Stars out in the quarter-final stage after beating them 2-1, with Van Egmond scoring in the game.
This game will see at least 23,500 fans awaiting the start of the Wave’s season at Snapdragon Stadium. This game will kick off on Sunday at 1:00 pm AEDT, international fans will be able to watch this season on the NWSL site.
Meanwhile, Alex Chidiac's Racing Louisville will travel to Texas for their opening game, taking on Houston Dash to start their season.
Racing finished in ninth place last season, with the side bolstering their side in the off-season with the addition of Brazilian international, Ary Borges and former North Carolina Courage duo, Abby Erecg and Carson Pickett.
This game will kick off on Monday morning at 10:00 am AEDT.
Sweden
Meanwhile, in Sweden, the OBOS Damallsvenskan season commences. Last season's champions Teagan Micah's FC Rosengård will host Piteå IF in their opening game of the season.
Rosengård will be aiming to turn around their pre-season luck when they start their season, with Micah not making an appearance during the Swedish Women's Cup group stage for the side.
This game will kick off on Saturday morning at 4:00 am AEDT.
Next up, Aivi Luik's BK Häcken will host Djurgårdens IF in their opening game, with the Wasps looking to start their season with a victory.
Häcken's pre-season saw them advance to the Swedish Women's Cup Final for a third consecutive season. This game will kick off on Monday morning at 12:30 am AEDT.
Meanwhile, Kyra Cooney-Cross' Hammarby will host Clare Polkinghorne, Katrina Gorry and Charli Grant's Vittsjö GIK, a replay of their final game of the season last year that saw Hammarby record a 2-1 win.
Cooney-Cross' team had a memorable pre-season, booking their spot in their first Swedish Women's Cup Final since 1995, and remaining undefeated in the group stage.
This game will kick off on Monday morning at 12:30 am AEDT.
France
In France, Ellie Carpenter's Lyon looks to increase their lead at the top of the D1 table when they host ninth-placed Guingamp, with OL having a one-point advantage at the top.
Their last meeting back in November ended in a 0-0 draw. This game will kick off on Sunday morning at 1:00 am AEDT.
Norway
Lastly, Tameka Yallop's SK Brann begins their title defence in the Toppserien when they face Lyn Fotball.
Brann's pre-season saw them face back-to-back draws, however, welcoming back Yallop from an ankle injury. This game will kick off on Sunday morning at 1:00 am AEDT.