Winonah Heatley's AS Roma will take on Juventus in the Serie A Cup final this weekend in a repeat of last year's matchup.
Elsewhere, Mary Fowler is looking to continue her goalscoring streak for Manchester City, Alana Murphy hopes to do the same for Nottingham Forest, and FC Rosengård have a huge weekend ahead as they hope to avoid relegation.
Read our preview of the action below.
England
WSL
Manchester City host Liverpool on Saturday, 4am AEST. The defending champions are two wins from two to start the season and will be hoping to continue that form against a Liverpool side who themselves remain undefeated to start. Mary Fowler has been on a hot streak, with a goal apiece in those games, and will be looking to make it three this weekend.
Charlton Athletic take on London City Lionesses on Saturday, 9.30pm AEST. Charlton are looking for their first point of the season while the Lionesses hope to bounce back after a disappointing result last time out. Emily van Egmond and Leah Davidson will be available to feature for Charlton while Alanna Kennedy is expected to feature for the Lionesses.
Ellie Carpenter’s Chelsea play Birmingham City on Saturday, 9.45pm AEST. Chelsea were dominant last weekend, with Carpenter scoring one of their five goals, and will hope to continue that form against the newly promoted Birmingham.
Arsenal host Manchester United on Sunday, 2.30am AEST. United are still without a point to start the new season, and their task doesn’t get any easier against the Gunners. Steph Catley, Kyra Cooney-Cross and Caitlin Foord will be available for Arsenal.
Brighton & Hove Albion take on Aston Villa on Sunday, 11pm AEST. Both sides are looking for their first win of the season. Charlie Rule will be available for the Seagulls.
Crystal Palace and Tottenham Hotspur face off on Sunday, 11pm AEST. Clare Hunt remains unavailable for Spurs, who have started the season with a win and a draw.
Finally, Everton travel to take on West Ham on Sunday, 11pm AEST. Holly McNamara will hope to continue the kind of form that saw her take out player of the match honours last time out, while Clare Wheeler will be available in midfield for the Toffees.
WSL2
Nottingham Forest travel to play Durham on Sunday, 1pm AEST. Both sides are looking for their first win of the new campaign. Alana Murphy and Leticia McKenna will be available for Forest.
Kaitlyn Torpey’s Newcastle United take on Sheffield United on Sunday, 11pm AEST. The Magpies are two wins from two to start the season and will hope to continue that form on the weekend.
Sweden
Malmö FF host Djurgarden on Saturday, 3am AEST. Malmö will be favourites for the match and could do fellow Aussies at Rosengård a favour with three points against the relegation battlers. Amy Sayer, Courtney Nevin and Charli Grant will be available for Malmö.
Daniela Galic’s Vittsjö GIK take on Växjö DFF on Saturday, 9pm AEST. Växjö are equal on points with Rosengård, below them on goal difference – so, once again, Galic and Vittsjö have the chance to pull off a massive result for Rosengård.
If their fellow Aussies can get the job done, it will be over to Bryleeh Henry, Isabel Gomez, Remy Siemsen and FC Rosengård as they take on IDK Norrköping on Sunday, 11pm AEST. A win could see Rosengård lift three points above any danger of relegation and up to seven points away from automatic relegation.
United States
Portland Thorns take on the Orlando Pride on Sunday, 6am AEST. The Thorns are three points away from the top four – but they’ll have one eye looking over their shoulder, too, with only a three-point buffer to dropping out of the finals entirely. Mackenzie Arnold will be expected to start in goal for the Thorns.
Gotham FC travel to take on the North Carolina Courage on Sunday, 8.30am AEST. A win will see them maintain their place five points clear on top of the table. Sam Kerr will be available for Gotham.
Germany
Eintracht Frankfurt take on Mainz on Saturday, 2.30am AEST. A win against bottom-of-the-table Mainz will help them keep pace with Bayern Munich and Wolfsburg at the top. Hayley Raso and Jamilla Rankin will be available for Frankfurt.
Italy
AS Roma take on Juventus in the Serie A Cup final on Sunday, 2am AEST. Roma will be keen for revenge after Juventus defeated them in the final last year. Winonah Heatley will be available for Roma.
Canada
Kahli Johnson’s Calgary Wild will be looking to extend their unbeaten run when they take on the Ottawa Rapid on Monday, 9am AEST. Johnson has made three goal contributions in their six-game unbeaten run.